Momwe Amuna ndi Akazi Amathandizira Kuopa Kukumbukira

Wolemba Ubongo & Khalidwe

Amuna ndi akazi ali ndi chiwopsezo chosiyanasiyana cha zoopsa- komanso zovuta zokhudzana ndi kupsinjika monga nkhawa komanso kupsinjika mtima pambuyo pake (PTSD), kafukufuku wakale adawululira. Mwachitsanzo, azimayi amadwala PTSD kawiri kuposa amuna. Ochita kafukufuku akufuna kudziwa chifukwa chake zili choncho.

Umboni wokulirapo ukuwonetsa kuti zochitika pakati pa amuna ndi akazi zimawopa kukumbukira mosiyanasiyana. Kafukufuku watsopano wama mbewa ochokera pagulu lotsogozedwa ndi 2016 BBRF Young Investigator Elizabeth A. Heller, Ph.D., waku University of Pennsylvania, akhazikitsa njira zina zomwe zikukhudzidwa. Kuzindikira njirazi kungathandizire kukulitsa mtsogolo chithandizo chazakugonana pazovuta zamankhwala.

Zotsatira zaposachedwa za gululi zidanenedwa pa intaneti mu Biological Psychiatry pa Disembala 5, 2018. Amati kuwongolera kwa jini yotchedwa Cdk5 ndichofunikira kwambiri pakusiyanitsa momwe amuna ndi akazi amatengera zikumbukiro. Kusiyana kunawoneka mu hippocampus yaubongo, likulu lokumbukira kukumbukira, kuphunzira, komanso malo.

Chisinthiko chinapanga njira zosiyanasiyana zomwe maselo amayendetsera ntchito ya majini awo-momwe amawatsegulira ndi kuzimitsa panthawi inayake. Njira zoyendetsera Cdk5 ndikusintha kwa kukumbukira kukumbukira kumatchedwa malamulo a epigenetic. Mtundu wamalamulo amtunduwu ndi chifukwa cha kusintha kwa ma molekyulu, otchedwa epigenetic alama, kuwonjezeredwa kapena kuchotsedwa mu magawo a DNA omwe "amatulutsa" majini. Powonjezera kapena kuchotsa zizindikiro za epigenetic, maselo amatha kuyambitsa kapena kutseka majini enaake.

Kugwiritsa ntchito mbewa monga zolowa m'malo mwa anthu-ubongo wama mbewa ndiwofanana m'njira zambiri, kuphatikiza njira zoyendetsera jini - Dr. Heller ndi anzawo adazindikira kuti kukumbukira kwakanthawi kwakanthawi kwamphamvu kuposa amuna. Chifukwa: kuchulukitsa kwa Cdk5 mwa amuna, chifukwa cha epigenetic. Kutsegulira kumachitika m'maselo amitsempha mu hippocampus.

Pogwiritsa ntchito njira yatsopano yotchedwa epigenetic editing, a Dr. Heller ndi anzawo adazindikira gawo lachikazi lachitetezo cha Cdk5 pofewetsa zomwe zingakumbukire za mantha. Izi zinali ndi zotulukapo zachikazi pazomwe zimachitika pambuyo poti jini ayambe kugwira ntchito.

Zomwe apezazi ndi gawo lakumvetsetsa kwathu kwakukula kwakusiyana pakati pa kugonana mu biology momwe zoopsa zimakumbukiridwira ndikuwonetsa chifukwa chake kugonana ndikofunikira muubongo ndi zovuta zamakhalidwe zomwe zimakhudza mantha ndi kupsinjika, monga PTSD, kukhumudwa, ndi nkhawa.