Zomwe Muyenera Kudziwa Zokhudza Kugona ndi Alzheimer's

Ndimagwira ntchito tsiku lililonse kuti ubongo wanga ukhale wabwino. Ndimawerenga, ndimasewera ndi ana anga (Mawu ndi Abwenzi, aliyense?), Ndimatengera zowonjezera, mumazitchula. Ndimadya chakudya chomwe chimagogomezera chakudya chamaubongo-kuphatikiza ma omega 3s omwe ndidalemba posachedwa. Ndimaonetsetsanso kuti ndimagona mokwanira.

Ndikugwira ntchito molimbika lero kuti luso langa lakuzindikira likhalebe lolimba kwazaka zambiri panjira.

Koma kukhala ndi moyo wathanzi sikungatipangitse kukhala opanda nkhawa zakubwera kwakanthawi kwakuchepa kwazindikiritso ndi matenda amanjenje monga matenda amisala. Odwala anga ambiri omwe akudutsa pakati pa zaka zapakati amakambirana nane za mantha awo otha kukumbukira, kuzindikira bwino, komanso magwiridwe antchito ndi ukalamba-komanso nkhawa zawo makamaka za Alzheimer's.

Pali kafukufuku watsopano wonena za kulumikizana pakati pa kugona ndi matenda a Alzheimer's ndikufuna kugawana nanu - kafukufuku yemwe amatithandiza kumvetsetsa zakugona mokwanira komanso matenda a Alzheimer's. Ambiri aife mwina timadziwa, kapena timamudziwa, munthu amene wakhudzidwa ndi matenda a Alzheimer's. Tsoka ilo, manambalawo akutsimikizira izi. Malinga ndi Alzheimer's Association, wina ku US amadwala matenda a Alzheimer pamasekondi 65 aliwonse. Masiku ano, pali anthu aku America 5.7 miliyoni omwe ali ndi matenda amitsempha iyi - matenda ofala kwambiri am'mutu. Pofika chaka cha 2050, kuyerekezera kuti chiwerengerochi chidzafika 14 miliyoni.

Kodi chimayambitsa matenda a Alzheimer's?

Yankho lolimba ndilakuti, mpaka pano sitikudziwa. Asayansi akuyesetsa kuti azindikire zomwe zimayambitsa matenda a Alzheimer's. Ngakhale sitikudziwa chifukwa chake, chomwe tikudziwa ndikuti matendawa amabweretsa zovuta zazikulu momwe magwiridwe antchito amaselo.

Ma neuron mabiliyoni ambiri mu ubongo wathu amakhala akugwira ntchito nthawi zonse, kutisunga amoyo ndikugwira ntchito. Amatithandiza kulingalira ndi kupanga zisankho, kusunga ndi kupeza zokumbukira ndi kuphunzira, kudziwa zomwe zatizungulira kudzera m'malingaliro athu, kumva malingaliro athu onse, ndikudziyankhula tokha mchilankhulo ndi machitidwe.

Asayansi akuganiza kuti pali mitundu ingapo yama protein yomwe imayambitsa kuwonongeka kwa ma cell amubongo, zomwe zimabweretsa zovuta zovuta pang'onopang'ono zokumbukira, kuphunzira, malingaliro, ndi machitidwe- zizindikiritso za Alzheimer's. Awiri mwa mapuloteniwa ndi awa:

• Mapuloteni a Beta-amyloid, omwe amapanga kuti apange mapangidwe ozungulira maselo aubongo.
• Mapuloteni a Tau, omwe amakula kukhala mfundo ngati zingwe - zotchedwa zingwe - m'maselo aubongo.

Asayansi akugwirabe ntchito kuti amvetsetse momwe zikwangwani ndi zingwe zimathandizira matenda a Alzheimer's ndi zizindikilo zake. Ndi ukalamba, ndizofala kuti anthu apange zina mwazomwe zimapangika muubongo. Koma anthu omwe ali ndi matenda a Alzheimer's amakhala ndi zikwangwani ndi zingwe zazikulu kwambiri - makamaka m'malo aubongo okhudzana ndi kukumbukira komanso magwiridwe antchito ena ozindikira.

Pali kafukufuku wochulukirapo yemwe akuwonetsa kuti kugona mokwanira komanso kusapeza tulo tokwanira kumalumikizidwa ndi kuchuluka kwa mapuloteni a beta-amyloid ndi tau muubongo. Kafukufuku wina yemwe adatulutsidwa mu 2017 adapeza kuti mwa achikulire athanzi, azaka zapakati, kusokonezeka kwa kugona pang'onopang'ono kumagwirizanitsidwa ndi kuchuluka kwa mapuloteni a beta-amyloid.

Kugona masana kumalumikizidwa ndi mapuloteni okhudzana ndi Alzheimer's muubongo

Kafukufuku amene wangotulutsidwa kumene akuwonetsa kuti kugona tulo masana kwambiri kumalumikizidwa ndi kuchuluka kwama protein amtundu wa beta-amyloid omwe amasungidwa kwa achikulire athanzi. Asayansi ku Mayo Clinic adafufuza kuti ayankhe funso lalikulu lokhudza zomwe zimachitika:

Chipatala cha Mayo chinali chitayamba kale kuphunzira kwakanthawi zakusintha kwakumvetsetsa komwe kumakhudzana ndi ukalamba. Kuchokera pa kafukufuku yemwe wachitika kale, asayansi adasankha anthu 283, omwe anali azaka zopitilira 70 ndipo analibe matenda amisala, kuti afufuze ubale womwe ulipo pakati pogona ndi zomwe amachita ndi beta-amyloid protein.

Kumayambiriro kwa kafukufukuyu, pafupifupi kotala limodzi - kuposa 22 peresenti ya achikulire omwe anali mgululi akuti adagona masana kwambiri.Kugona tulo tofa nato masana, ndichizindikiro chachikulu kuti simukugona mokwanira usiku — ndipo ndi chizindikiro chokhudzana ndi vuto la tulo, kuphatikizapo kusowa tulo.

Kwazaka zisanu ndi ziwiri, asayansi adayang'ana zochitika za odwala-amyloid ogwiritsa ntchito sikani za PET. Apeza:

Anthu omwe amakhala ndi tulo tamasana kwambiri kumayambiriro kwa phunziroli amatha kukhala ndi beta-amyloid pakapita nthawi.

Mwa anthu osagonawa, kuchuluka kwa beta-amyloid kumangidwa kumachitika m'malo awiri aubongo: anterior cingate ndi cingulate precuneus. Mwa anthu omwe ali ndi Alzheimer's, magawo awiriwa aubongo amakonda kuwonetsa kuchuluka kwa beta-amyloid buildup.

Kafukufukuyu samapereka yankho lotsimikizika ku funso loti ngati kugona mokwanira kumayendetsa mapuloteni amyloid, kapena madipoziti amyloid omwe akuyambitsa mavuto ogona-kapena ena onse awiri. Koma zikusonyeza kuti kugona tulo masana kungakhale chizindikiro choyamba cha matenda a Alzheimer's.

Kafukufuku wa Mayo Clinic akugwirizana ndi kafukufuku waposachedwa kwambiri yemwe adayang'ana ubale womwe ulipo pakati pa kugona tulo tofooka ndi chiwopsezo cha Alzheimer's. Asayansi ku Yunivesite ya Wisconsin, Madison adasanthula kulumikizana komwe kungakhalepo pakati pa kugona ndi zikwangwani zingapo zofunikira za Alzheimer's, zomwe zimapezeka mumtsempha wamtsempha, kuphatikiza zikwangwani zamapuloteni a beta-amyloid ndi mapuloteni a tau omwe amatsogolera ku zingwe zopindika zama cell.

Pakafukufukuyu, asayansi adayesa anthu omwe alibe Alzheimer's kapena dementia-koma adasankha makamaka omwe ali pachiwopsezo chachikulu cha matendawa, mwina chifukwa anali ndi kholo lomwe lili ndi Alzheimer's kapena chifukwa anali ndi jini inayake (apolipoprotein E gene), yomwe imakhudzana ndi matendawa.

Mofanana ndi anzawo ku Mayo, ofufuza a Madison adapeza kuti anthu omwe amakhala ndi tulo tambiri masana adawonetsa zambiri zamapuloteni a beta-amyloid. Anapezanso tulo masana olumikizidwa ndi zolembera zambiri zama protein a tau. Ndipo anthu omwe akuti sankagona bwino komanso anali ndi mavuto ochuluka ogona adawonetsa zambiri zamagetsi a Alzheimer's kuposa anzawo ogona tulo.

Ubongo umadziyeretsa ndi mapuloteni okhudzana ndi Alzheimer tulo

Zinali zaka zingapo zapitazo pomwe asayansi adapeza kachitidwe kosadziwika kale muubongo kamene kamachotsa zinyalala, kuphatikiza mapuloteni a beta-amyloid omwe amapezeka ndi Alzheimer's. (Yunivesite ya Rochester Medical Center asayansi omwe adapeza izi adatcha "glymphatic system," chifukwa imagwira ntchito mofanana kwambiri ndi machitidwe amitsempha amthupi pochotsa zinyalala mthupi, ndipo amagwiritsidwa ntchito ndimaselo am'magazi am'bongo.) t mungotchula dongosolo la glymphatic - chinthu chodziwikiratu chomwe chimapezeka mwa icho chokha. Anapezanso kuti machitidwe a gimphatic amapita patsogolo kwambiri akagona.

Tikagona, asayansi apeza kuti, glymphatic system imagwira ntchito kangapo pochotsa zinyalala muubongo.

Izi ndi zina mwazofufuza zolimbikitsa kwambiri komabe kuwonetsa kufunikira kwa kugona mokwanira kuumoyo waubongo kwakanthawi. Mukamagona, asayansi akuganiza tsopano, dongosolo lanu la masewera olimbitsa thupi likuwonjezera ntchito yake kuti ichotse zinyalala zomwe zingakhale zowononga tsiku lanu lonse. Ngati mumagona mokwanira kapena simukugona mokwanira pafupipafupi, mumakhala pachiwopsezo chophonya zotsatira za kuyeretsa uku.

Nthawi zosagona bwino zogwirizana ndi Alzheimer's

Chizindikiro china chokhudzana ndi kugona kwa Alzheimer's? Kusokoneza magonedwe, malinga ndi kafukufuku watsopano. Asayansi ku Washington University School of Medicine adatsata mayendedwe azizungulira komanso magonedwe okalamba pafupifupi 200 achikulire (azaka zapakati, 66), ndikuwayesa onse asanakwane, zizindikiritso za Alzheimer's pre-hospital.

Mwa odwala 50 omwe adawonetsa zizindikiro za matenda a Alzheimer's, onsewa adasokoneza magonedwe ogona. Izi zikutanthauza kuti matupi awo sanali kutsatira njira yodalirika yogona usiku ndi zochitika masana. Amatha kugona pang'ono usiku, ndipo amakonda kugona kwambiri masana.

Chofunika kudziwa apa: Anthu omwe anali mu phunziroli omwe adasokoneza magonedwe oyaluka sikuti onse anali atagona tulo. Anali kugona mokwanira — koma anali akugonera tulo tating'onoting'ono patsiku la maola 24.

Kafukufukuyu akuwonetsa kuti kusokonezeka kwa mayendedwe a circadian kumatha kukhala kachilombo koyambitsa matenda a Alzheimer's, ngakhale atasowa tulo.

Odwala anga akandiuza nkhawa zawo zokhudzana ndi thanzi lawo lalitali komanso mantha awo a Alzheimer's, ndikumvetsetsa. Ndikukuuzani zomwe ndiwauze: chinthu chabwino kwambiri chomwe mungachite ndikutanthauzira nkhawa zanu kukhala njira zodzitetezera ndikudzisamalira lero, ndi cholinga chochepetsera chiopsezo chanu chazidziwitso m'maganizo. Kuyang'ana zonse zomwe tikudziwa, zikuwonekeratu kuti kugona mokwanira, kugona bwino ndi gawo lofunikira pazochitikazo.

Maloto abwino,
Michael J. Breus, PhD, DABSM
Dokotala Wogona ™
www.kamachikoma.com