Umboni pa Melatonin Wokusowa Tulo

Ngati mwakhalapo ndi vuto la kugona, mukudziwa kuwawa kwakanthawi kofuna kugona pomwe thupi lanu silingagwirizane. Ndi vuto wamba; akuti pafupifupi 10 peresenti ya anthu okhala kumadzulo amapezeka kuti ali ndi vuto lalikulu la kugona ndipo 25% amakumana ndi mavuto masiku ambiri ndi kugona kapena kutopa masana.

M'zaka zaposachedwa, melatonin yakhala njira yotchuka. Mahomoni amapangidwa mwachilengedwe ndi thupi kuti lizitha kuyendetsa kayendedwe ka circadian, kuphatikiza kuwongolera tulo tomwe timagona. (Matupi athu amapanga melatonin ikafika nthawi yoti agone, ndipo siyani kuyipanga ikafika nthawi yodzuka m'mawa.) Ku United States ndi Canada, melatonin imagulitsidwa pa-counter ngati chowonjezera cha zakudya.

Ofufuza apanga kafukufuku mazana ambiri pazokhudza zotsatira za melatonin pazinthu zosiyanasiyana - kuyambira pa jet lag mpaka zovuta za kugona kwa aliyense kuyambira ana mpaka odwala omwe ali ndi vuto. Ndipo mzaka zingapo zapitazi, magulu angapo ofufuza adasanthula umboni wa melatonin. Nazi zomwe apeza:

Ndemanga yomwe idasindikizidwa munyuzipepalayi Ndemanga Zamankhwala Akugona mu 2017 anaphatikiza umboni kuchokera kumayeso 12 osasinthika komanso owongoleredwa omwe amayang'ana momwe melatonin imagwirira ntchito kuthana ndi vuto loyambirira la kugona mwa akulu. Owunikanso adapeza umboni wokhutiritsa wakuti melatonin imagwira ntchito pothandiza anthu kuti agone mwachangu ndikuthandizira akhungu kuwongolera magonedwe awo.

Kwa ana, ndemanga yomwe idasindikizidwa mu 2014 mu Zolemba pa Psychology ya Ana anaphatikiza umboni kuchokera kumayeso 16 osinthidwa mosiyanasiyana kuti apeze ngati melatonin ingathandize ana omwe ali ndi vuto la kugona. Ofufuzawo adapeza kuti melatonin imathandizira ana omwe ali ndi vuto logona kuti agone mwachangu kwambiri, amadzuka pang'ono usiku uliwonse, amagonanso mwachangu akamadzuka, ndikugona mokwanira usiku uliwonse.

Kuwunika kwakale kwambiri, kofalitsidwa ndi Cochrane Collaboration mu 2002, kunapezeka kuti melatonin ndi yothandiza popewa ndikuchepetsa zizindikilo za jet, makamaka kwa apaulendo omwe akudutsa nthawi zisanu kapena kupitilira apo kulowera kum'mawa.

Pazonse, pali umboni wotsimikizika kuti melatonin imatha kuthandiza anthu kugona ndi kuwongolera mawotchi awo amkati. Munthawi yochepa, palibe umboni wazovuta zoyipa. Ndemanga zitatuzi zikuwonetsa kuti palibe umboni uliwonse wazomwe zingachitike mukatenga melatonin.

Koma pali vuto: Chifukwa melatonin imagulitsidwa ngati chowonjezera pazakudya, kapangidwe kake sikatsatiridwa ndi US Food and Drug Administration.

Kafukufuku wofalitsidwa chaka chatha mu Zolemba pa Clinical Sleep Medicine tafufuza zomwe zili ndi zowonjezera 31 za melatonin zochokera kuzinthu zosiyanasiyana. Ofufuza apeza kuti zomwe zimapezeka mu melatonin zowonjezera zimasiyana kwambiri poyerekeza ndi zilembo zawo — kuyambira 83% yochepera kuposa yotsatsa mpaka 478 peresenti kuposa yomwe idalengezedwa. Ochepera 30 peresenti ya zowonjezera zomwe adayesedwa anali ndi muyeso womwe udalembedwa. Ndipo ofufuza sanapeze mtundu uliwonse wamitundu yofananira ndi mitundu inayake, zomwe zimapangitsa kukhala kosatheka kwa ogula kudziwa kuchuluka kwa melatonin omwe akupeza.

Kuphatikiza apo, zowonjezera zisanu ndi zitatu za phunziroli zinali ndi timadzi tina tating'onoting'ono-serotonin-yomwe imagwiritsidwa ntchito pochiza kukhumudwa ndi zovuta zina zamitsempha. Kutenga serotonin mosadziwa kumatha kubweretsa zovuta zoyipa.

Mlingo ndi vuto. Kuwunika mwatsatanetsatane kwa 2005 komwe kudasindikizidwa munyuzipepalayi Ndemanga Zamankhwala Akugona anapeza kuti melatonin imagwira ntchito kwambiri pamlingo wa 0,3 milligrams. Koma mapiritsi a melatonin omwe amagulitsidwa amakhala ndi kuchuluka kwakanthawi kokwanira ka 10. Pamlingo umenewo, zotengera za melatonin muubongo zimakhala zosalabadira.

Ulendo wopita kunyumba: Ngakhale melatonin imatha kukuthandizani pamavuto anu ogona, palibe njira yotsimikizika yothetsera kuchuluka kwa mahomoni panthawi ino.